A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Sethi, R. K.
- Optimization of Coating Solution for Preparation of Sustained Release Tablet
Authors
1 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228(MP), IN
2 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228 (MP), IN
3 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone-451228 (MP), IN
4 Department of Pharmaceutics, GRY Institute of Pharmacy Borawan, Khargone- 451228 (MP), IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 3 (2009), Pagination: 204-206Abstract
In this study, tablets were formulated by wet granulation technique taking Paracetamol as model drug. Three mucoadhesive polymers namely hydroxyl propyl methyl cellulose K4M, methyl cellulose and poly vinyl pyrolidone were used for preparation of coating solution (1%,2% and 3%) as well as for development of sustained release tablets. All the evaluation were carried out before and after coating like thickness and diameter, weight variation, friability, disintegration, swelling index, Mucoadhesive strength, drug content and in-vitro release study. All the physical evaluation parameters were increases after coating when compare with normal tablet. Normal tablets were showed 95% release within 30 min where coated tablets showed 98% release over a period of 6hr. in water and release was diffusion controlled confirmed by Higuchi’s plot. Thus, the present study concluded that, we can development of sustained release formulation can be possible by coating using the mucoadhesive polymers.Keywords
Punch, Coating, Diffusion, Sustained- Effect of Dispersing Agent on the Characteristics of Eudragit Microspheres
Authors
1 University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar-751004, IN
2 University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar – 751004, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 2, No 1 (2010), Pagination: 67-71Abstract
Eudragit RS microspheres containing Indina vir sulphate for oral use were prepared using two different dispersing agents: aluminium stearate and magnesium stearate, by solvent evaporation method. The effects of the type and concentration of the dispersing agents and the inner phase polymer concentration on the size of microspheres was studied. The morphology of microspheres was characterized by scanning electron microscopy. The surface of microspheres prepared with aluminium stearate was smoother and non-porous. When magnesium stearate was used as dispersing agents, the particle size of microspheres decreased. Increasing amounts of this dispersing agent led to the accumulation of their free particles onto the surfaces of the microspheres. The drug release from the microspheres was faster with the microspheres from aluminium stearate based on their hydrophobic structures. The encapsulation efficiency is more in case of aluminium stearate in comparison to magnesium stearate. Formulation containing aluminium stearate shows a more sustained effect than formulation containing magnesium stearate. This may due to fact that aluminium stearate is more hydrophobic in comparison to magnesium stearate.